Deposel - Slow release Selenium

Benefits Summary:

• One product providing long acting selenium supplementation for sheep and cattle
• Easy to administer - simple subcutaneous injection
• Peace of mind
• Cost effective
• Administered using standard vaccination equipment
• Safe - high safety margin in both cattle and sheep
• Protects lambs and calves which are suckling treated mothers

Formulation:

Deposel contains SO mg/mL selenium as barium selenate. Barium selenate has extremely low solubility and it is this feature which allows Deposel to provide long-term selenium supplementation. When injected, the barium selenate forms a depot beneath the skin which slowly releases selenium over time. Deposel contains a yellow pigment that allows easy identification and trimming of any injection site residues that may remain at slaughter.

When can DEPOSEL be administered?

DEPOSEL can be used all year round and has no meat or milk withholding periods in cattle.

Suggested times of administration include:

Lambs and Calves

• At weaning.

Breeding Ewes, Cows and Heifers

• 4-8 weeks prior to joining

Bulls and Rams

• Prior to mating

Dairy Cows

• At drying off

Selenium Deficiency in Australia

Selenium is an essential trace element for animals, but has no known role in plants. Pasture that is improved, lush and green may look like it contains all nutrients necessary but may actually be deficient in Selenium. Selenium deficiencies can cause significant losses in fertility and production. It is well recognised that selenium supplementation can result in a significant increase in productivity, especially when animals are suspected of having less than optimal selenium levels.

The Role of Selenium in the body

Selenium is vital for the formation of the antioxidant enzyme glutathione peroxidase which is active in many tissues, especially the liver. Selenium helps to protect animal tissue from damage, particularly muscle, enabling growth and production. Selenium also helps to maintain the immune system, lower the risk of infection and improve fertility and conception rates.

In what situations are selenium deficiencies more likely to occur?

• On pasture growing on acid or sandy soils
• Where the average rainfall is over 450mm per year
• If the use of superphosphate ("super") is common
• Coastal areas
• On clover dominant pasture
• In young growing animals

Common Methods of Diagnosing Selenium Deficiency

• Selenium levels in the blood and liver
• Glutathione peroxidase levels in blood
• Selenium levels in the milk of lactating cows

Signs of Selenium Deficiency

The majority of selenium deficiencies experienced in Australia are marginal deficiencies that may escape detection but still result in ill-thrift and a reduction in fertility and productivity.

Marginal Selenium Deficiency can lead to:

• Lower growth rates ("poor doers")
• Reduced fertility, lower conception rates and longer returns to service
• Reduced wool growth
• Mastitis (sub-clinical and clinical)
• Higher somatic cell counts in milk
• Decreased milk production
• Scours
• Increased susceptibility to infection and disease
• Ill-thrift

The most common result of clinical selenium deficiency is White Muscle Disease.

Injection for Cattle and Sheep.

How should DEPOSEL be administered?

Deposel is administered as a subcutaneous injection high on the neck just behind the ear. Raise the skin into a tent and insert the needle parallel to the body ensuring the injection is placed under the skin and not into the muscle. Using a needle less than 15 mm long will reduce the chance of an intra muscular injection occurring.

Occasionally a skin reaction can occur over the injection - site. These swellings should not be painful, develop into abscesses or result in hair loss.This reaction resolves over time. An intra muscular injection may cause a more serious reaction and care must be taken to ensure that this does not occur.

To avoid carcass damage ensure that all injection apparatus are sterilised by boiling before use. Needles should be kept clean at all times and replaced frequently.

DEPOSEL can be administered using standard vaccination equipment. Applicator guns tested for compatibility with Deposel include:

For Sheep:
NJ Phillips 1 and 2mL vaccinators, the Genesis 2.5mL Palm grip and 2mL EZ-Doser , the Simcro-Tech 2mL vaccinator and the Instrument Supplies 2mL Vaxinate and 2mL V-Vaxinate.

For Cattle:
Instrument Supplies The Optimiser 12.5mL, Genesis EZ Grip 10mL Vaccinator, Simcro-Tech 10mL Vaccinator.

Dose Rates:
Deposel is administered at the rate of lmL per 50 kg in both sheep and cattle, equivalent to 1mg selenium per kg bodyweight. Packaging Deposel is available in two convenient multi-dose bladder pack sizes- 200mL and 500mL.

DEPOSEL and Dairy Herds

Selenium supplementation has been proven to significantly increase milk yield and productivity in dairy herds. DEPOSEL has no milk withholding period in cattle and is easily administered.

Using a Selenium supplement such as DEPOSEL in dairy cattle has been shown to:

• Increase conception rates, including first service rates
• Reduce number of stillbirths
• Reduce afterbirth complications ie retained foetal membranes
• Reduce calving intervals
• Lower milk somatic cell counts
• Reduce mastitis
• Improve daily milk yield

Safety

The safety and tolerance of DEPOSEL has been investigated in both cattle and sheep. Studies have shown DEPOSEL to be safe at twice the recommended dose rate. Trials have also demonstrated that DEPOSEL is safe for pregnant cows and ewes when administered at the recommended dose rate The administration of DEPOSEL at the recommended dose rate was also tested to be safe in cows and sheep not deficient in selenium.

Product Handling and storage

• Store below 25°C
• Store in the original container, tightly closed, away from foodstuffs
• Unopened Deposel has a two year shelf life
• Once Deposel has been opened, use within 28 days

First Aid

If additional hazard information is required, refer to the Material Safety Data Sheet. For a copy please phone 1800 633 768.

Withholding Periods

• Meat: Nil
• Milk: (Cattle): Nil
  (Sheep): DO NOT USE in lactating animals where milk or milk products may be used for human consumption